Mycobacterium Igituntu INH Kurwanya

Ibisobanuro bigufi:

Iki gikoresho gikoreshwa mukumenya neza ihinduka ryimiterere ya gene ya 315th amino acide ya gene ya katG (K315G> C) hamwe na mutation ya gene yakarere ka porotokoro ya InhA (- 15 C> T).


Ibicuruzwa birambuye

Ibicuruzwa

izina RY'IGICURUZWA

HWTS-RT002A-Mycobacterium Igituntu Isoniazid Kurwanya Kurwanya Ibikoresho (Fluorescence PCR)

Icyemezo

Myanmar FDA

Epidemiologiya

Isoniazid, umuti w'ingenzi urwanya igituntu watangijwe mu 1952, ni umwe mu miti ifatika yo kuvura igituntu gikora hamwe n'umuti umwe w’igituntu cyihishe.

KatG ni gene nyamukuru ikubiyemo catalase-peroxidase na mutG gene ihinduka irashobora guteza imbere synthesis yurukuta rwa selile ya mycolike, bigatuma bagiteri zirwanya isoniazid.Imvugo ya KatG ihujwe nabi nimpinduka muri INH-MIC, no kugabanuka inshuro 2 mumagambo ya katG bivamo kwiyongera gato gato inshuro 2 muri MIC.Indi mpamvu itera kurwanya isoniazid muri mycobacterium igituntu kibaho mugihe kwinjiza, gusiba cyangwa guhinduka bibaye muri InhA gene locus ya mycobacterium igituntu.

Umuyoboro

ROX inhA (-15C> T) urubuga ·
CY5

urubuga katG (315G> C)

VIC (HEX)

IS6110

Ibipimo bya tekiniki

Ububiko ≤-18 ℃ Mu mwijima
Ubuzima bwa Shelf

Amezi 12

Ubwoko bw'icyitegererezo

Amacandwe

CV ≤5.0%
LoD

1 × 103bagiteri / mL

Umwihariko Nta reaction ya cross-reaction hamwe na mutation yibibanza bine birwanya ibiyobyabwenge (511, 516, 526 na 531) bya gene ya rpoB hanze yurwego rwo gutahura ibikoresho.

Ibikoresho bikoreshwa:

Ikoreshwa rya Biosystems 7500 Sisitemu-Igihe nyacyo PCR

Ikoreshwa rya Biosystems 7500 Byihuse-Igihe-Sisitemu ya PCR

QuantStudio®5 Sisitemu-Igihe nyacyo PCR

SLAN-96P Sisitemu nyayo-PCR

UmucyoCycler®480 Sisitemu nyayo-PCR

LineGene 9600 Yongeyeho Sisitemu-Igihe Cyuzuye PCR

MA-6000-Igihe-Cyuzuye Cyumubare Wubushyuhe

BioRad CFX96 Sisitemu-Igihe Cyuzuye PCR

BioRad CFX Opus 96 Sisitemu Yigihe-PCR

Urujya n'uruza rw'akazi

4697e0586927f02cf6939f68fc30ffc


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