Mycobacterium Igituntu Rifampicin Kurwanya

Ibisobanuro bigufi:

Iki gikoresho kirakwiriye kugirango hamenyekane ihindagurika ryimiterere ihindagurika ryabahuje ibitsina muri 507-533 aminide acide codon yo mu karere ka rpoB itera Mycobacterium igituntu rifampicin irwanya.


Ibicuruzwa birambuye

Ibicuruzwa

Izina RY'IGICURUZWA

HWTS-RT074A-Mycobacterium Igituntu Rifampicin Kurwanya Kurwanya Ibikoresho (Fluorescence PCR)

Epidemiologiya

Rifampicin yakoreshejwe cyane mu kuvura abarwayi b'igituntu cy'ibihaha kuva mu mpera za za 70, kandi igira ingaruka zikomeye.Nibwo buryo bwa mbere bwo kugabanya chimiotherapie y’abarwayi b’igituntu.Kurwanya Rifampicin biterwa ahanini na mutation ya rpoB.Nubwo imiti mishya yo kurwanya igituntu ihora isohoka, kandi n’ubuvuzi bw’abarwayi b’igituntu cy’ibihaha nabwo bwakomeje gutera imbere, haracyari ikibazo cyo kubura imiti igabanya ubukana, kandi ikibazo cyo gukoresha ibiyobyabwenge bidafite ishingiro mu mavuriro ni kinini.Ikigaragara ni uko igituntu cya Mycobacterium ku barwayi bafite igituntu cy'igituntu kidashobora kwicwa mu gihe gikwiye, amaherezo kikaba kiganisha ku ntera zitandukanye zo kurwanya ibiyobyabwenge mu mubiri w'umurwayi, bikongera inzira y'indwara, kandi byongera ibyago byo gupfa k'umurwayi.Iki gikoresho gikwiranye no gusuzuma indwara zifasha indwara ya Mycobacterium igituntu no kumenya gene irwanya rifampicin, ifasha mu gusobanukirwa imiti igabanya ubukana bwa mycobacterium yanduye abarwayi, no gutanga uburyo bufasha bwo kuyobora imiti ivura.

Epidemiologiya

 

Izina ry'intego Umunyamakuru Quencher
BufferA BufferB BufferC
rpoB 507-514 rpoB 513-520 IS6110 FAM Nta na kimwe
rpoB 520-527 rpoB 527-533 / CY5 Nta na kimwe
/ / Kugenzura imbere HEX (VIC) Nta na kimwe

 

Ibipimo bya tekiniki

Ububiko

≤-18 ℃ Mu mwijima

Ubuzima bwa Shelf

Amezi 9

Ubwoko bw'icyitegererezo

Amacandwe

CV

< 5 %

LoD

ubwoko bwa rifampicin-bwihanganira ubwoko: 2x103bagiteri / mL

mutant bahuje igitsina: 2x103bagiteri / mL

Umwihariko

Itahura ubwoko bwigituntu cyitwa mycobacterium igituntu hamwe na mutation yizindi genes zirwanya ibiyobyabwenge nka katG 315G> C \ A, InhA-15C> T, ibisubizo byikizamini byerekana ko bitarwanya rifampicine, bivuze ko nta reaction-cross-reaction.

Ibikoresho bikoreshwa:

SLAN-96P Sisitemu nyayo-PCR (Hongshi Medical Technology Co., Ltd.)

Urujya n'uruza rw'akazi


  • Mbere:
  • Ibikurikira:

  • Andika ubutumwa bwawe hano hanyuma utwohereze