Vuba aha,CDC y'Ubushinwa buri cyumweruyasohoye inkuru y'ingenzi y'ubushakashatsi ivuga ku icyorezo cy'indwara yo mu nda n'inkomoko y'indwara yatewe na virusi ya rotavirusi yo mu itsinda rya C (RVC) mu ishuri ribanza rya Luzhou, mu Ntara ya Sichuan, mu Ukwakira 2025. Ikigaragara ni uko uburyo bwa Macro & Micro-Test bwo gufata udukoko twinshi (probe-capture) hamwe n'ikoranabuhanga ryo gusesengura genome yose bwagize uruhare runini mu iperereza. Binyuze mu gutuma habaho kumenya neza udukoko no kugaragaza neza genome, ikoranabuhanga ryatanze ibimenyetso by'ingenzi bya siyansi kugira ngo byemezwe vuba icyorezo, hamenyekane neza aho cyaturutse, kandi hagenzurwe neza icyorezo.
Icyorezo gitunguranye: Icyorezo cya mbere cya RVC cyavuzwe mu majyepfo y'uburengerazuba bw'u Bushinwa
Ku ya 15 Ukwakira 2025, icyorezo cy’igifu cyabaye mu ishuri ribanza rya Luzhou. Iri shuri ryari rifite abanyeshuri n’abakozi 1.943, aho abantu 32 bagaragaye, harimo 6 bemejwe muri laboratwari n’abandi 26 basuzumwe mu buvuzi, bituma umubare w’abarwaye indwara wazamukaho 1.65%. Icyorezo cyageze ku rwego rwo hejuru hagati ya 15 na 16 Ukwakira, aho abanyeshuri bo mu cyiciro cya 7, mu mwaka wa 5 bagaragayeho igipimo cyo hejuru cy’ibitero (23.08%). Abarwayi benshi bari abana bari mu kigero cy’ishuri (imyaka iri hagati: imyaka 10), bagaragazaga cyane cyane kuruka (65.62%), impiswi (46.87%), no kubabara mu nda (37.50%). Ibimenyetso byakunze kumara iminsi 1-3, kandi abarwayi bose barakize nta ngorane zikomeye.
Iperereza ry’ibiza ryagaragaje ko uyu musore ari umuhungu w’imyaka 11 wiga mu mwaka wa 7, mu mwaka wa 5. Mushiki we muto yari yaragize ibimenyetso nk’ibyo mbere ye, bigaragaza ko ubwandu bwo mu rugo ari bwo bwa mbere bwaturutse. Kutavura ibirutsi mu ishuri—harimo no gukaraba no guta amazi nta gusukura ku gihe cyangwa gushyira ahantu hiherereye—hamwe n’isuku nke y’intoki mu banyeshuri, byashoboraga gutuma habaho kwandura. Ibyumba byinshi by’amashuri byagizweho ingaruka byari biri hagati y’igorofa rya kabiri n’irya gatanu hamwe n’ubwiherero bw’abagabo bwari buhuriweho, bigaragaza ko umwuka n’ubwandu bishobora kuba byaragize uruhare mu ikwirakwira ry’ibi birungo.
Iperereza ryabaye ingorabahizi cyane kuko gupima indwara buri gihe, harimo no gupima virusi ya norovirusi na virusi ya rotavirusi yo mu itsinda rya A, byatanze ibisubizo bibi, bigaragaza ko hari indwara idasanzwe yanduza iyi ndwara.
Isuzuma ry'Inkomoko y'Indwara: Uburyo bwo Gupima Genome Yuzuye bwa Macro na Micro-Test bugaragaza Uwagize Icyaha
Isuzuma rya mbere rya norovirusi ryagaragaje ko nta virusi itera SIDA yagaragaye. Nyuma yaho, CDC ya Luzhou yakoresheje uburyo bwa PCR bwo gusuzuma indwara y’igifu ishobora gupima indwara 28 icyarimwe, harimo virusi 8, bagiteri 17, n’udukoko 3, kugira ngo hasuzumwe ingero umunani z’indwara. Ku ya 17 Ukwakira, ingero esheshatu zagaragaye ko zanduye virusi ya rotavirusi yo mu itsinda rya C, maze zigaragaza neza iyo ndwara.
Kugira ngo barusheho gukurikirana aho icyorezo cyaturutse, abashakashatsi bakoze sequencing ya nanopore metagenomic ndetse na Macro & Micro-Test's probe-catch whole-genome enrichment sequencing ku bipimo bitanu byagaragaje ko ari byiza. Ubu buryo bwatanze neza sequences eshanu zuzuye za RVC genome (SC01–SC05). Ingamba zihuriweho zo gusuzuma byihuse multiplex PCR hagakurikiraho sequencing ya whole-genome ifite ubushobozi bwo hejuru zatanze inkunga ikomeye ya tekiniki yo kumenya neza uko ibintu biteye no gukurikirana aho ibintu bikomoka.
Ubumenyi bwa siyansi: Imenyekana rya mbere rya M2 Genotype mu majyepfo y'uburengerazuba bw'u Bushinwa
Ishingiye ku makuru y’ingirabuzimafatizo yuzuye yakozwe hakoreshejwe ikoranabuhanga rya Macro & Micro-Test, itsinda ry’ubushakashatsi ryatangaje ibintu byinshi by’ingenzi byavumbuwe mu bya siyansi:
Kwemeza icyorezo cya monoclonal:Udukoko twose dutanu twa virusi twari dusangiye ubwoko bumwe bwa genome yose (G4-P[2]-I2-R2-C2-M2-A2-N2-T2-E2-H2), dufite itandukaniro rya 0-1 gusa rya nucleotide imwe (SNP), bigaragaza neza ko icyorezo cyaturutse ku ruhererekane rumwe rw’ikwirakwizwa ry’indwara.
Ivumburwa rya genotype ya M2:Isesengura rya phylogenetic ryagaragaje ko ubwoko bwa Luzhou RVC bwari ubwo mu bwoko bwa M2 aho kuba ubwoko bwa M3 bwari busanzwe bufatwa nk'ubwiganje mu bwoko bwa RVC bwo mu Bushinwa. Ibi bibangamira imyumvire isanzwe y'ikwirakwizwa rya RVC mu Bushinwa kandi byemeza ko ubwoko bwa M2 bwavutse mu majyepfo y'uburengerazuba bw'Ubushinwa.
Ibimenyetso by'aho itumanaho mpuzamahanga rihurira:Igereranya rya genome yose ryagaragaje isano iri hagati y’ubwoko bwa Luzhou n’ubwoko bwa RVC bwavuzwe mbere muri Yunnan (2025), Novosibirsk, mu Burusiya (2017), no mu Butaliyani (2012), bigaragaza ko hariho umuyoboro ukorera mu Burayi.
Ingaruka zo gukumira no kurwanya: Gutahura hakiri kare no gutabara byihuse ni ingenzi
Nyuma yo kumenya indwara ziterwa n’iyi ndwara, CDC ya Luzhou yahise ishyiraho ingamba zirambuye zo kuyirwanya, zirimo gushyira mu kato abanduye, kwica udukoko mu bidukikije, gucunga ibirutsi mu buryo busanzwe, no guhagarika by’agateganyo icyorezo. Icyorezo cyarahagaritswe neza mu gihe kimwe cyo kwibasira, nta bandi banduye bagaragaye nyuma ya 21 Ukwakira.
Iperereza ritanga kandi isomo ry'ingenzi ku buzima rusange: ku ndwara z’igifu zigaragara nk’izifite agakoko gatera indwara ya rotavirus yo mu itsinda rya A na norovirus, virusi ya rotavirus yo mu itsinda rya C n’izindi virusi za rotavirus zitari izo mu itsinda rya A zigomba gushyirwa mu isuzuma risanzwe.
Ubu bushakashatsi bugaragaza icyorezo cya mbere cya rotavirusi yo mu itsinda rya C cyagaragaye mu majyepfo y'uburengerazuba bw'Ubushinwa ndetse n'uburyo bwa mbere bwo kumenya ubwoko bwa M2 muri ako karere, bikongera ubumenyi bugezweho ku ndwara ya RVC muri Aziya y'Iburasirazuba. Muri ubu bushakashatsi, igisubizo cya Macro & Micro-Test gihuriweho gihuza gusuzuma PCR nyinshi hamwe n'uburyo bwo gukusanya imiterere ya genome yose cyagaragaje akamaro gakomeye mu gutuma habaho kumenya indwara vuba no gukurikirana inkomoko ya molekile mu buryo bworoshye, bitanga uburyo bwo kongera gukora iperereza no kugenzura indwara zandura mu gihe kizaza.
Igihe cyo kohereza: 30 Nyakanga-2026