Kuva ku bimenyetso kugeza ku gikoresho: Ibisobanuro bya Porofeseri Susan Huang ku igenzura rya MRSA n'uruhare rwa POCT yihuta ya molekile

—-“MRSA iracyari ikibazo gikomeye. Imodoka y’abarwayi itera imbaraga mu gutwara abantu n’ibintu. Kugenzura ntibisaba ingamba gusa - ahubwo bisaba umuvuduko n’ubuhanga ku rugamba.”

Akaga gahoraho ka MRSA

Muri iki gihe, MRSA iracyari imwe mu mpamvu zikomeye zitera kwandura indwara ziterwa n’ibitaro. Mu kiganiro cye cya ESCMID Global 2026, Porofeseri Susan Huang wo muri UC Irvine yatanze amakuru ateye ubwoba: muri Leta Zunze Ubumwe za Amerika honyine, hafiIndwara 120.000 za S. aureus mu marasobibaho buri mwaka, hamweabapfuye bagera ku 20.000bifitanye isano itaziguye n’izi ndwara. MRSA iri mu mpamvu zikomeye zitera kwandura indwara zo mu gace k’ubuvuzi, umusonga, n’indwara zo mu maraso, kandi ikomeje kuba imwe mu mpamvu zikomeye zitera kwandura indwara zituruka mu bitaro (HAI) mu bana.

Igituma MRSA igorana cyane kuyigenzura ni uko yoroshya kwanduzanya. Ndetse no guhurirana n’abarwayi buri gihe bishobora kwanduza abakozi bo mu rwego rw’ubuvuzi, hatitawe ku ruhare rwabo cyangwa aho baherereye. Iyo umurwayi amaze kwanduzwa na MRSA, urwego rw’abayirwaye rushobora kumara amezi cyangwa imyaka, bigatuma ikwirakwira mu nzego z’ubuvuzi. Ubushakashatsi bumwe bwavuzwe na Porofeseri Huang bwagaragaje ko10–14% by'abarwayi bafite ikibazo cyo kwandura indwara ya MRSA barwara indwara ikomeye mu mwaka umwe nyuma yo kuva mu bitaro.

Ingamba eshatu zo kugenzura ubu: Kureka, Gushaka, Kwagura

Porofeseri Huang yashyize hamwe ingamba zo kugenzura MRSA mu bitaro mu buryo butatu:

1. Relent – ​​Ingamba z'ibanze zihamye, igenzura rito
Iyi ngamba ihindura intego kuva ku "gukuraho burundu" ikajya ku bikorwa bikwirakwira mu bitaro byose, harimo isuku y'intoki, gusukura uruhu rurwanya udukoko, no kwirinda kwandura hakoreshejwe ibikoresho. Hamwe n'ubufasha bukomeye bwo kugenzura, igipimo cy'ubwandu bwa MRSA gishobora kugabanuka. Ariko, ingaruka ni nke, kandi umutwaro munini w'ubwandu uracyari hanze y'inkuta z'ibitaro.

2. Intego - Gusuzuma byimazeyo + gukuraho ubukoloni kugira ngo habeho uburyo nyabwo bwo gukemura ikibazo
Ubu buryo bushimangira kumenya abanduye indwara binyuze mu kugenzura neza kugira ngo habeho uburyo bwo gutabara hakiri kare - cyane cyane uburyo bwo gukuraho ubukoloni. Kubera ko ubwandu bwinshi bwa MRSA buturuka ku bwoko bw'izuru ry'umurwayi, gukuraho ubukoloni bugamije kurwanya indwara bishobora kugabanya cyane ibyago byo kwandura. Byagaragaye ko bigira ingaruka nziza ku barwayi babazwe ndetse n'abamaze kuva mu bitaro. Inyungu iragaragara, ariko iyi ngamba isaba amikoro arambye.

3. Kwagura – Ubufasha bwagutse ku nyungu nyinshi
Ingamba za Expand zemeza ko abarwayi bakunze gutwara udukoko twinshi icyarimwe, bigatuma uburyo bwo gukoresha udukoko twinshi butagira ingaruka nziza. Uburyo bwo gusukura uruhu mu buryo butambitse nko gukoresha imiti yica udukoko (harimo cyangwa nta miti ikoreshwa mu mazuru) bushobora kugabanya umutwaro wa MRSA n'izindi ndwara icyarimwe. Igerageza rinini ryagaragaje ko iyi ngamba ari yo ifite akamaro kanini mu kugabanya MRSA n'indwara zo mu maraso, ndetse no gutanga uburinzi mu kugabanya umutwaro w'udukoko muri rusange mu barwayi.

Ingamba zo guhuza no gushyira mu bikorwa: Uruhare rw'ibizamini byihuse kandi byoroshye kubona

Ingamba zose uko ari eshatu - Relent, Target, na Expand - zisangiye ibisabwa:kumenya ku gihe kandi neza ubwiyongere bwa MRSA cyangwa ubwandu.Hatabayeho kumenyekana vuba:

-Relentntamu gihe nyacyoibitekerezo kugira ngo hakosorwe ingamba z'ibanze.

-Integontishobora gusuzuma no gukuraho ubukoloni neza idahinduye imikorere vuba.

-Kwagurainyungu zo kumenya uburyo bw'ibanze bwo kugenzura ingaruka.

Aha niho ibizamini bya Macro na Micro-TestUrubuga rwa POCT rwuzuye rwa AIO800+SA & MRSA ibikoresho byo gutahura aside nucleicgutanga ikiraro cy'ingenzi hagati y'ingamba z'amasomo n'ukuri kw'ubuvuzi.

Igisubizo cya Macro & Micro-Test: Gukoresha buri ngambahamwe naIshingiroibintu bidasanzwe

-Intego:gene y'ingirabuzimafatizo(by'umwihariko kuri S. aureus) +gene ya mecA(ubudahangarwa bwa methicillin)

-Ibisubizo muriIminota 30–60(ugereranyije n'iminsi 2–3 yo kwita ku muco)

- Ubwoko bw'ingero: amatembabuzi, isuku yo mu mazuru, ingero z'uruhu/ingingo zoroshye

-Gutanga umusaruro uturutse mu miyoboro y'umwimerere (1.5–12 mL); igihe gito cyo gukora

-Imiterere ibiri y'ibinyabutabire (ibikomoka ku mazi n'ibikomoka kuri lyophilized) yo kubika/gutwara ibintu mu buryo bworoshye

-Kugenzura ubwandu bw'ibice 11 (UV, HEPA, gufunga parafini, nibindi)

-Impamyabumenyi: IVDR, NMPA, FDA, MDA

Uburyo ishyigikira buri ngamba:

Inyuma y'inkuta z'ibitaro

Umushinga mushya wa Porofeseri Huang uterwa inkunga na miliyoni nyinshi z'amadolari ugaragaza inzira yagutse kandi ikomeje kwiyongera mu gukumira ubwandu: kwagura uburyo bwo kugenzura MRSA burenze ibitaro, hibandwa ku banduye nyuma yo kuva mu bitaro. Igishushanyo mbonera cya AIO800 gikozwe mu buryo bwikora gihuye cyane n'iyi filozofiya. Uru rubuga rukwiriye cyane mu gushyigikira impinduka zigana ku gupima abantu mu buryo bwihuse - bigatuma MRSA iboneka vuba kandi byoroshye gukoreshwa mu mavuriro yo hanze, mu bigo nderabuzima, no mu bigo bishobora kwita ku bantu mu ngo, aho ahazaza ho gukumira ubwandu hagana.

Kuva ku ngamba kugera ku gisubizo

Porofeseri Susan Huang yahaye umuryango mpuzamahanga ushinzwe kurwanya ubwandu urwego rw’ingamba zisobanutse: Relent, Target, and Expand. Ariko ingamba zidafite ibikoresho byo gushyira mu bikorwa ziracyari intego gusa. Porogaramu ya Macro & Micro-Test ya AIO800 POCT hamwe na SA & MRSA detection kit itangaumuvuduko, ubworoherane, no kugera ku byo umuntu ashobora kubonabikenewe kugira ngo izi ngamba zihindurwemo ukuri kwa buri munsi - muriICU, ibyumba rusange, ndetse amaherezo n'inyuma y'ibitaro.