Icyerekezo gikomeye BCR-ABL Kumenya kuvura CML

Indwara ya myelogenousleukemia idakira (CML) n'indwara mbi ya clone ya selile hematopoietic stem selile. Abarwayi ba CML barenga 95% batwara chromosome ya Philadelphia (Ph) mungirangingo zabo. Kandi gene ya BCR-ABL ikorwa no guhinduranya hagati ya ABL proto-oncogene (Abelson murine leukemia virusi oncogene homologi 1) kumaboko maremare ya chromosome 9 (9q34) na gene ya cluster point (BCR) gene kumaboko maremare ya chromosome 22 (22q11). Poroteyine yo mu bwoko bwa fusion yashizwemo niyi gen ifite ibikorwa bya tyrosine kinase (TK), kandi ikora inzira yayo yerekana inzira (nka RAS, PI3K, na JAK / STAT) kugirango iteze imbere amacakubiri no kubuza apoptose selile, bigatuma selile ziyongera nabi, bityo bigatuma CML ibaho.

BCR-ABL fusion gene, ifite akamaro mugutezimbere CML, ikora nkikimenyetso cyingenzi cyo gusuzuma ya CML. Kumenya kwayo bifasha gukurikirana umurwayi's igisubizo kuri tyrosine kinase inhibitor (TKIs) kandi iteganya ko leukemia izongera kubaho, ningirakamaro mugucunga neza abarwayi ba CML.

Umuntu BCR-ABLIbikoresho bya Fusion Gene Mutationkuva muri Macro & Micro-Ikizamini cyo kumenya neza BCR-ABL mu barwayi ba CML, ifasha gusuzuma CML ikanayobora imiti ivura kunoza ingamba zo kuvura zo gucunga neza abarwayi.BCR-ABL fusion geneningombwamu iterambere rya CML,ni nk'ibimenyetso by'ingenzi byo gusuzumaofCML. Kumenya bifashagukurikiranaihangane'sigisubizo kuri tyrosine kinase inhibitor (TKIs)naiteganya ko leukemia izongera kubaho, ningombwato ingirakamaroCMLgucunga abarwayi.

Umuntu BCR-ABL Fusion Gene Mutation Detection Kit kuva muri Macro & Micro-Ikizamini cyo kumenya neza BCR-ABL mu barwayi ba CML, ifashaCMLgusuzumanaKuyoboraintego yo kuvuratooptimizeingamba zo kuvura zo gucunga neza abarwayi.

ByuzuyeDgutora:IcyarimwegutahuraKuri3ingirabuzimafatizo rusange (P210, P190, P230)Kurikwaguka nogukumira imanza zabuze;

Ubushishozi bukabije:Amazi ya verisiyo yerekana genes ya fusionhamwe na LoDya kopi 1000 / mL,na verisiyoof Kopi 500 / mL;

CyizaAccuracy: Iimberekugenzuraenzyme ya UNG kugirango ikumire ibyiza bitari byo&ibibi;

Gukora Byoroshye no Gukora neza:Igikorwa gifunze,nta bicuruzwanyuma yo gutunganya,nagutahuraimbereIminota 60Kuriibisubizo bifatika kandi byizewe;

IbindiAmahitamo：Amazi meza na lyofilized verisiyo kubakiriya bahitamo;

Ubwuzuzanye bwagutse:Bihujwe na sisitemu nyinshi za PCR kugirango laboratwari yagutse.