Umuntu BCR-ABL Fusion Gene Mutation

Ibisobanuro bigufi:

Iki gikoresho gikwiranye no kumenya neza p190, p210 na p230 isoforms ya gen ya BCR-ABL fusion gene mubigero byamagufa yabantu.


Ibicuruzwa birambuye

Ibicuruzwa

Izina RY'IGICURUZWA

HWTS-GE010A-Umuntu BCR-ABL Fusion Gene Mutation Detection Kit (Fluorescence PCR)

Epidemiologiya

Indwara ya myelogenousleukemia idakira (CML) ni indwara mbi ya clone ya selile hematopoietic stem selile.Abarwayi ba CML barenga 95% batwara chromosome ya Philadelphia (Ph) mungirangingo zabo.Indwara yanduye ya CML niyi ikurikira: Gene ya BCR-ABL fusion ikorwa no guhinduranya hagati ya abl proto-oncogene (Abelson murine leukemia virusi oncogene homolog 1) kumaboko maremare ya chromosome 9 (9q34) n'akarere ka cluster () BCR) gene kumaboko maremare ya chromosome 22 (22q11);poroteyine ya fusion yashizwemo niyi gen ifite ibikorwa bya tyrosine kinase (TK), kandi ikora ibikorwa byayo byerekana inzira (nka RAS, PI3K, na JAK / STAT) kugirango iteze imbere amacakubiri no kubuza apoptose selile, bigatuma selile ziyongera nabi, bityo bigatera ibibaho bya CML.BCR-ABL ni kimwe mu bipimo byingenzi byo gusuzuma bya CML.Ihinduka ryinshi ryurwego rwinyandiko-mvugo ni ikimenyetso cyizewe cyo guca imanza za leukemia kandi zishobora gukoreshwa mu guhanura indwara ya leukemia nyuma yo kuvurwa.

Umuyoboro

FAM BCR-ABL fusion gene
VIC / HEX Igenzura ryimbere

Ibipimo bya tekiniki

Ububiko Amazi: ≤-18 ℃ Mu mwijima
Ubuzima bwa Shelf Amazi: amezi 9
Ubwoko bw'icyitegererezo Ingero z'amagufwa
LoD Amakopi 1000 / mL

Umwihariko

 

Nta reaction-reaction hamwe nizindi genes zo guhuza TEL-AML1, E2A-PBX1, MLL-AF4, AML1-ETO, na PML-RARa
Ibikoresho bikoreshwa Ikoreshwa rya Biosystems 7500 Sisitemu-Igihe nyacyo PCR

Ikoreshwa rya Biosystems 7500 Byihuse-Igihe-Sisitemu ya PCR

QuantStudio® 5 Sisitemu nyayo-PCR

SLAN-96P Sisitemu nyayo-PCR

UmucyoCycler®480 Sisitemu nyayo-PCR

LineGene 9600 Yongeyeho Sisitemu-Igihe Cyuzuye PCR

MA-6000-Igihe-Cyuzuye Cyumubare Wubushyuhe

BioRad CFX96 Sisitemu-Igihe Cyuzuye PCR

BioRad CFX Opus 96 Sisitemu Yigihe-PCR


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