MTHFR Gene Polymorphic Nucleic Acide

Acide Folike ni vitamine ikabura amazi ni cofactor ya ngombwa mu nzira zo guhinduranya umubiri.Mu myaka yashize, umubare munini w’ubushakashatsi wemeje ko, ihinduka rya folate metabolizing enzyme gene MTHFR bizatera kubura aside folike mu mubiri, kandi kwangirika kwinshi kubura aside folike ku bantu bakuru bishobora gutera anemiya ya megaloblastique, imitsi kwangirika kwa endoteliyale, nibindi. Kubura aside folike ku bagore batwite ntibishobora guhaza ibyo bakeneye ubwabo ndetse n’uruyoya, bishobora gutera inenge zifata imitsi, anencephaly, kubyara, no gukuramo inda.Urwego rwa serumu folate rwibasiwe na 5,10-methylenetetrahydrofolate reductase (MTHFR) polymorphism.677C> T na 1298A> C ihindagurika muri gene ya MTHFR itera ihinduka rya alanine kuri valine na aside glutamic, bigatuma ibikorwa bya MTHFR bigabanuka bityo bikagabanya ikoreshwa rya aside folike.