KRAS 8 Guhinduka

Guhindura ingingo muri gene ya KRAS byagaragaye mubwoko butandukanye bwibibyimba byabantu, hafi 17% ~ 25% ihinduka ryimiterere yibibyimba, 15% ~ 30% ihinduka ryimiterere yabarwayi ba kanseri yibihaha, 20% ~ 50% bya mutation kubarwayi ba kanseri yibara. Kuberako poroteyine ya P21 yashizwemo na gene ya K-ras iherereye hepfo yumuhanda wa EGFR werekana inzira, nyuma ya mutation ya K-ras, inzira yerekana ibimenyetso ihora ikora kandi ntigire ingaruka kumiti yibasiwe na EGFR, bigatuma habaho kwiyongera kwingirabuzimafatizo. Guhinduka kwa gene ya K-ras muri rusange bitanga imbaraga zo kurwanya EGFR tyrosine kinase inhibitor ku barwayi ba kanseri y'ibihaha no kurwanya imiti igabanya ubukana bwa EGFR ku barwayi ba kanseri yibara. Mu mwaka wa 2008, ikigo cy’igihugu gishinzwe kurwanya kanseri (NCCN) cyasohoye umurongo ngenderwaho w’ubuvuzi bwa kanseri yibara, cyerekanye ko aho ihinduka ry’imiterere itera K-ras rikorwa cyane cyane riri muri kode ya 12 na 13 za exon 2, anasaba ko abarwayi bose barwaye kanseri y’imyororokere yateye imbere bashobora kwipimisha K-ras mbere yo kuvurwa. Kubwibyo, kumenya vuba na neza K-ras ihindagurika rya gene bifite akamaro kanini mubuyobozi bwo kuvura imiti. Iki gikoresho gikoresha ADN nk'icyitegererezo cyo gutahura kugira ngo gitange isuzuma ryujuje ubuziranenge bw'imiterere ya mutation, ishobora gufasha abaganga gusuzuma kanseri y'urura runini, kanseri y'ibihaha ndetse n'abandi barwayi b'ibibyimba bungukirwa n'ibiyobyabwenge. Ibisubizo by'ibizamini by'ibikoresho ni ibyavuzwe gusa kandi ntibigomba gukoreshwa nk'ishingiro ryonyine ryo kuvura abarwayi ku giti cyabo. Abaganga b’amavuriro bagomba gufata imyanzuro yuzuye kubisubizo by’ibizamini hashingiwe ku bintu nk’umurwayi umeze, ibimenyetso by’ibiyobyabwenge, igisubizo cy’ubuvuzi n’ibindi bipimo bya laboratoire.