Umuntu Ros1 Fusion Gen Mutation

Ros1 ni tyrosine tyrostine umuryango wumuryango wa reseptor wa Receptar. RES1 GEE ya ROS1 yemejwe nkindi gene ya kanseri ya kanseri idafite kanseri. Nkuhagararwa muri molecpe nshya idasanzwe, intambwe ya ros1 fusion muri NSCLC igera kuri 1% kugeza kuri 2% cyane kuri exon 32, 34, 35 na 36. Nyuma yacyo yahujwe na CD74, Ezr, SLC34A2, na SDC4, bizakomeza gukora akarere ka Ros1 Tyrosine Kinase. Ibikorwa bidasanzwe bya ros1 kinase birashobora gukora inzira yamakuru nka ras / MAPK / Mtor, hamwe na Jakt na Metor, na Metor na Metriasis yingirabuzimafatizo, kandi bigatera kanseri. Mu majwi ya Ros1 acecetse, CD74-ROS1 kuri 42%, EZR hafi 15%, SLC34A2 igera kuri 12%, na SDC4 kuri 7%. Ubushakashatsi bwerekanye ko ahantu hatangijwe na kataletic domaine ya Ros1 Kinase hamwe na ARHIRDINE HANZE HANZE COREPOLOTINE HAMWE NA COLECOOLE HAMWETION KANDI HANO GUKORA Ingaruka zo gukiza Mu kuvura NSCLC hamwe na Fusion Mutution ya Ros1. Kubwibyo, gutahura ros1 kuzenguruka ihinduka ryambere nibyingenzi byo kuyobora ikoreshwa ryibiyobyabwenge bya cnzinine.