Umuntu EML4-Alk Fusion Gen Mutation

Iyi kin ikoreshwa mu buryo bujuje ubuziranenge bwa 12 Imiterere ya Eml4-ALK Fusion insegs yabarwayi ba kanseri badafite ibihaha bya Kanseri ya Kanseri. Ibisubizo by'ibizamini ni ibya clinique byemewe kandi ntibigomba gukoreshwa nkishingiro ryonyine ryo kuvura abantu ku giti cyabo. Abaganga bagomba guca imanza byuzuye kubisubizo byikizamini bishingiye kubintu nkuko umurwayi ameze, ibimenyetso biranga ibiyobyabwenge, igisubizo cyo kuvura, nibindi bisobanuro byikizamini. Kanseri y'ibihaha ni ikibyimba gikunze kugaragara ku isi, kandi 80% ~ 85% by'imanza ni kanseri idafite kanseri zitari gito (NSCLC). Gen Fusion ya Echinodermic Microtubuye ya Echinoder Miliyoni shingiro ebyiri. Nibura ibice 20 bikurikirana byabonetse, muribitana 12 bahine mu mbonerahamwe ya 1 birasanzwe, aho Mutant 1 (E13; A20), hakurikiraho mutants 3a na 3b 33% na 29% by'abarwayi hamwe na Eml4-alk Fusion gene naclc, nibindi. ALK ibibujijwe bihagarariwe na cnzitinib ni ibiyobyabwenge bito-byateye molecule byateguwe kubihinduka bya alk Gee Surs Surs Surs Surs. Mugubuza ibikorwa bya ALK Tyrosine Kinase, guhagarika inzira zayo zidasanzwe, bityo zibuza imikurire yingirabuzimafatizo, kugirango ugere ku buvuzi bwibibyimba. Ubushakashatsi bwa clinical bwerekanye ko cnzitinib ifite igipimo cyiza kirenze 61% kubarwayi bakoresheje Eml4-alk sfuosion muguhinduka, mugihe nta ngaruka ku barwayi bo mu gasozi. Kubwibyo, kumenya EML4-alk Urutonde Mutation nigikorwa nishingiro ryo kuyobora ikoreshwa ryibiyobyabwenge bya cnzinine.