EgFR muntu Gene 29 Mutation

Kanseri y'ibihaha yabaye intangiriro yo kumena kanseri ku isi hose, itera ubwoba ubuzima bwabantu. Konti zitari nke za Kanseri ya Kanseri zingana na 80% byabarwayi ba kanseri. EGFR kuri ubu ni intego ikomeye cyane yo kuvura kanseri idacumbike. Fososhorylation ya EGFR irashobora guteza imbere imikurire y'ibibyimba, ihungabana, gutera, metissis, kurwanya anti-apoptose, no guteza imbere ikibyimba. EgFR Tyrosine Kinase Abagizi ba nabi (TKE) barashobora guhagarika inzira yamashusho ya EGFR, bityo bibuza ingirabuzimafatizo, bigabanya ibibyimba bya axor Umubare munini wubushakashatsi werekanye ko imikorere yubuvuzi bwa egfr-tki ifitanye isano rya hafi nuburyo bwa egfr gene, kandi irashobora kubuza gukura kwa selile yibibyimba hamwe na tatution ya egfr gene. Gene ya egfr iherereye ku kuboko kugufi ya chromosome 7 (7p12), hamwe n'uburebure bwuzuye bwa 200kb kandi igizwe na 28 exons. Akarere ka Mitote kari giherereye ahanini muri Exons 18 kugeza 21, Codans 746 kugeza 753 Gusiba kuri Exon 19% na L858r kuri 40% kuri 45%. Amabwiriza ya NCCN yo gusuzuma no kuvura kanseri ntoya y'ibihaha ibihaha ibihaha ibihaha ibihaha ivuga ko ibizamini bya EgFr Gen Mutution bisabwa mbere y'ubuyobozi bwa EGFR-TKI. Iki kizamini gikoreshwa mu kuyobora ubuyobozi bw'imikurire ya Epidermal Respartor Tyrofisor Ikiyobyabwenge (EGFR-TKI) ibiyobyabwenge, kandi bitanga ishingiro ry'imiti yihariye ku barwayi bafite kanseri idafite kare. Iyi kikoresho ikoreshwa gusa kugirango iburamubiri ihuriweho muri egfr gene kubarwayi bafite kanseri idafite kanseri nto. Ibisubizo by'ibizamini ni ibya clinique byemewe kandi ntibigomba gukoreshwa nkishingiro ryonyine ryo kuvura abantu ku giti cyabo. Abavuriro bagomba gutekereza ku mibabaro, ibimenyetso by'ibiyobyabwenge, no kuvura reaction n'ibipimo by'ibizamini bya laboratoire hamwe n'ibindi bintu bikoreshwa mu kutitaho ibisubizo by'ikizamini.