Umuntu Cyp2C9 na vkorc1 Gene Polymorphism

Warfarin ni anticoagulant yo mu kanwa isanzwe ikoreshwa mumyitozo ya kavukire kuri ubu, igamije cyane cyane gukumira no kuvura indwara za Thromineeme. Ariko, Warfarin afite idirishya rinini kandi riratandukanye cyane mumoko ndetse n'abantu ku giti cyabo. Imibare yagaragaje ko itandukaniro ryibipimo bihamye mubantu bitandukanye bishobora kuba inshuro zirenga 20. Amaraso mabi aboneka muri 15.2% byabarwayi bafata Warfarin buri mwaka, muri bo 3.5% bakura amaraso yica. Ubushakashatsi bwa Pharmacogenomic bwerekanye ko gellmorphisiti ya generam ya ogrambh enzyme vkorc1 na metabolike enzyme Cyp2C9 ni ikintu cyingenzi kigira ingaruka ku itandukaniro muri dose ya Warfarin. Warfarin ni uwumubujije umwihariko wa Vitamine K Epoxide (Vkorc1), bityo akabuza rero ibiryo synthesis irimo vitamine K no gutanga anticoagulation. Umubare munini w'ubushakashatsi werekanye ko Gene Polymorphism ya Vkorc1 aricyo kintu cyingenzi kigira ingaruka ku isiganwa no gutandukanya umuntu wa Arfarin. Warfarin ni metabolied na Cyp2C9, kandi mutantrat yo buhoro cyane ya Warfarin. Abantu bakoresha Warfarin bafite ibyago byinshi (inshuro ebyiri kugeza inshuro eshatu) zo kuva amaraso mugihe cyambere cyo gukoresha.