Umuntu Cyp2c19 Gene Polymorphism

Cyp2c19 nimwe mubiyobyabwenge byingenzi byimitsi mumuryango wa Cyp450. Inkombe nyinshi za endogenous kandi hafi 2% yimiti yubuvuzi ni metero2c19, nka metabolism ya antiolet ya antiplalet (nka cloton pomptrel), nibindi Cyp2C19 ifite itandukaniro mubushobozi bwumurongo wa Bifitanye isano ibiyobyabwenge. Iyi ngingo ihinduka * 2 (rs4244285) na * 3 (rs4986893) genura ibihome bya metabo2c19, no kongera ibitekerezo byamaraso byashyizweho Amaraso. * 17 (rs1248560) irashobora kongera ibikorwa bya enzyme byashyizwe kuri Cyp2c19 gene, umusaruro wa metabolite, kandi uzamure imibumbe itera imbere kandi yongere ibyago. Kubantu bafite metabolism yibiyobyabwenge, bafata dosiye isanzwe igihe kirekire bizatera ingaruka zikomeye hamwe ningaruka mbi: ahanini ibyangiritse, byangiritse kuri sisitemu yo hagati, nibindi bishobora kuganisha ku rupfu rwibibazo bikomeye. Ukurikije itandukaniro kugiti cye mubiyobyabwenge bihuye, muri rusange bigabanywamo ibintu bine, ni ukuvuga metabolism ya ultra-yihuta (um 17 / * 17 / * 17 / * 1 / * 1 / * 1 / * 1 / * 1 / * 1 / * 1 / * 1 / * 1 / * 1 / * 1 / * 1 / * 1 / * 1 / * 1 / * 1 / * 1 / * 1 / * 1 ), hagati ya metabolism (im, * 1 / * 2, * 1 / * 3), metabolism (PM, * 2 / * 2, * 2 / * 2, * 2 / * 2, * 3 / * 3).