Umuntu CYP2C19 Gene Polymorphism

CYP2C19 nimwe mumyanya ikomeye ya metabolizing enzymes mumuryango wa CYP450.Imiti myinshi ya endogenous hamwe na 2% byimiti yubuvuzi ikoreshwa na CYP2C19, nka metabolism ya antiplatelet agregation inhibitor (nka clopidogrel), inhibitori ya proton pompe (omeprazole), anticonvulsants, nibindi CYP2C19 gene polymorphism nayo ifite itandukaniro mubushobozi bwa metabolizing. ibiyobyabwenge bifitanye isano.Ihinduka ry’ingingo ya * 2 (rs4244285) na * 3 (rs4986893) ritera gutakaza ibikorwa bya enzyme byashyizweho na gene CYP2C19 nintege nke zubushobozi bwimikorere ya metabolike, kandi bikongera umuvuduko wamaraso, kugirango bitere ingaruka mbi zibiyobyabwenge bijyanye kwibanda kumaraso.* 17.Ku bantu bafite metabolisme itinda yibiyobyabwenge, gufata inshuro zisanzwe igihe kirekire bizatera uburozi bukomeye ningaruka: cyane cyane kwangirika kwumwijima, kwangirika kwa sisitemu ya hematopoietic, kwangirika kwimitsi yo hagati, nibindi, bishobora gutera urupfu mubihe bikomeye.Ukurikije itandukaniro ryabantu ku giti cyabo muburyo bwo guhinduranya ibiyobyabwenge, muri rusange bigabanyijemo fenotipa enye, arizo metabolism yihuta cyane (UM, * 17 / * 17, * 1 / * 17), metabolism yihuse (RM, * 1 / * 1 ), metabolism hagati (IM, * 1 / * 2, * 1 / * 3), metabolism itinda (PM, * 2 / * 2, * 2 / * 3, * 3 / * 3).