Umuntu CYP2C19 Gene Polymorphism

CYP2C19 nimwe mumiti ikomeye ya metabolizing enzymes mumuryango wa CYP450. Imiti myinshi ya endogenous substrate hamwe na 2% yimiti ivura ikoreshwa na CYP2C19, nka metabolism ya antiplatelet agregation inhibitor (nka clopidogrel), inhibitori ya proton pompe (omeprazole), anticonvulsants, nibindi CYP2C19 gene polymorphism nayo ifite itandukaniro mubushobozi bwo guhinduranya imiti. Ihinduka ry'ingingo ya * 2 (rs4244285) na * 3 (rs4986893) ritera gutakaza ibikorwa bya enzyme byashyizweho na gen CYP2C19 n'intege nke z'ubushobozi bwo guhinduranya insimburangingo, kandi bikongera umuvuduko w'amaraso, kugirango bitere ingaruka mbi zibiyobyabwenge bijyanye no kwibanda kumaraso. * 17. Ku bantu bafite metabolisme itinda yibiyobyabwenge, gufata inshuro zisanzwe igihe kirekire bizatera uburozi bukomeye ningaruka: cyane cyane kwangirika kwumwijima, kwangirika kwa sisitemu ya hematopoietic, kwangirika kwimitsi yo hagati, nibindi, bishobora gutera urupfu mubihe bikomeye. Ukurikije itandukaniro ryabantu ku giti cyabo muri metabolisme ihuye n’ibiyobyabwenge, muri rusange igabanyijemo fenotipa enye, arizo metabolisme yihuta cyane (UM, * 17 / * 17, * 1 / * 17), metabolism yihuta (RM, * 1 / * 1), metabolism hagati (IM, * 1 / * 2, * 1 / * 3), metabolism itinda (PM, * 2 / * 2, * 2 * * 3).