Impinduka mu mikorere ya za gene za BCR-ABL zo mu bwoko bwa Human BCR-ABL Fusion
Izina ry'igicuruzwa
HWTS-GE010A-Human BCR-ABL Fusion Gene Mutation Detection Kit (Fluorescence PCR)
HWTS-GE016A-Human BCR-ABL Fusion Gene Mutation Detection Kit (Fluorescence PCR) yumye mu buryo bwa frigo
Ubumenyi bw'indwara
Indwara ya myelogenousleukemia idakira (CML) ni indwara mbi ifata uturemangingo tw’amaraso. Abarenga 95% by’abarwayi ba CML bafite chromosome ya Philadelphia (Ph) mu turemangingo tw’amaraso yabo. Impamvu nyamukuru ya CML ni iyi ikurikira: Gene ya BCR-ABL fusion ikorwa no guhurira hagati ya abl proto-oncogene (Abelson murine leukemia viral oncogene homolog 1) ku kuboko kure kwa chromosome 9 (9q34) na gene ya breakpoint cluster region (BCR) ku kuboko kure kwa chromosome 22 (22q11); poroteyine ya fusion ishingiye kuri iyi gene ifite imikorere ya tyrosine kinase (TK), kandi igakoresha inzira zayo zo mu nzira zo hasi (nka RAS, PI3K, na JAK/STAT) kugira ngo iteze imbere ukwigabanya kw’uturemangingo no gukumira apoptosis y’uturemangingo, bigatuma uturemangingo twiyongera cyane, bityo bigatuma CML ibaho. BCR-ABL ni kimwe mu bimenyetso by’ingenzi by’isuzuma rya CML. Impinduka mu buryo bugaragara ku rugero rw'inyandiko yayo ni ikimenyetso cyizewe cyo gupima kanseri y'amaraso mu gihe cy'ibizamini, kandi gishobora gukoreshwa mu kumenya ko kanseri y'amaraso izagaruka nyuma yo kuvurwa.
Umuyoboro
| FAM | Ingirabuzimafatizo za BCR-ABL |
| VIC/HEX | Igenzura ry'imbere |
Ibipimo bya tekiniki
| Ububiko | Amazi: ≤-18℃ Mu mwijima |
| Igihe cyo kumara | Amazi: Amezi 9 |
| Ubwoko bw'ingero | Ingero z'umusemburo w'amagufwa |
| LoD | Kopi 1000 / mL |
| Ubwihariye
| Nta buryo bwo guhuza imiterere y'uturemangingo (reactivity) hamwe n'izindi gene za fusion TEL-AML1, E2A-PBX1, MLL-AF4, AML1-ETO, na PML-RARa |
| Ibikoresho Bikoreshwa | Sisitemu za PCR zikoreshwa mu gihe nyacyo 7500 Sisitemu za PCR zikoreshwa mu buryo bwihuse 7500 Sisitemu 5 za PCR za QuantStudio® mu gihe nyacyo Sisitemu za PCR za SLAN-96P mu gihe nyacyo Sisitemu ya LightCycler®480 Real-Time PCR Sisitemu yo Gusuzuma PCR ya LineGene 9600 Plus mu gihe nyacyo MA-6000 Umuvuduko w'ubushyuhe mu gihe nyacyo Sisitemu ya BioRad CFX96 ya PCR mu gihe nyacyo Sisitemu ya BioRad CFX Opus 96 ya PCR mu gihe nyacyo |
