Umuti w'umutekano wa Aspirine

Aspirine, nk'umuti urwanya guteranya kw'imitsi, ikoreshwa cyane mu gukumira no kuvura indwara z'umutima n'imitsi yo mu bwonko. Ubushakashatsi bwagaragaje ko abarwayi bamwe basanze badashobora guhagarika neza imikorere ya platelets nubwo bakoresha aspirine ku gipimo gito igihe kirekire, ni ukuvuga ubudahangarwa bwa aspirine (AR). Igipimo kiri hagati ya 50% na 60%, kandi hari itandukaniro rigaragara ry'amoko. Glycoprotein IIb/IIIa (GPI IIb/IIIa) igira uruhare runini mu guteranya kw'imitsi no gutera amaraso mu buryo bukabije ahantu hakomeretse imitsi. Ubushakashatsi bwagaragaje ko imiterere y'imitsi igira uruhare runini mu guteranya kw'imitsi, cyane cyane yibanda kuri GPIIIa P1A1/A2, PEAR1 na PTGS1 polymorphisms. GPIIIa P1A2 niyo gene nyamukuru irwanya aspirine. Impinduka muri iyi gene zihindura imiterere ya receptor za GPIIb/IIIa, bigatuma habaho isano hagati ya platelets na platelets. Ubushakashatsi bwagaragaje ko inshuro za alele za P1A2 ku barwayi badafite aspirine zari nyinshi cyane ugereranyije n’iz’abarwayi bakunze aspirine, kandi abarwayi bafite imihindagurikire ya P1A2/A2 homozygous mutations bagiraga ingaruka mbi nyuma yo gufata aspirine. Abarwayi bafite alele za P1A2 zitagize icyo zikora baterwa stenting bafite igipimo cya subacute thrombotic events gikubye gatanu ugereranyije n’abarwayi ba P1A1 homozygous wild-type, bakeneye dose nyinshi za aspirine kugira ngo bagere ku ngaruka zo kurwanya amaraso. Allele ya PEAR1 GG ikira neza aspirine, kandi abarwayi bafite genotype ya AA cyangwa AG bafata aspirine (cyangwa ivanze na clopidogrel) nyuma yo gushyirwamo stent bafite indwara nyinshi zo mu mutima n’urupfu. Genotype ya PTGS1 GG ifite ibyago byinshi byo kudakira aspirine (HR: 10) kandi ikaba ifite ibyago byinshi byo kugira indwara z’umutima n’amaraso (HR: 2.55). Genotype ya AG ifite ibyago biri hagati, kandi hakwiye kwitabwaho cyane ingaruka zo kuvura aspirine. Genotype ya AA irushaho kuba nziza kuri aspirine, kandi ingaruka z’indwara z’umutima n’amaraso ni nkeya. Ibisubizo byo kuvumbura iki gicuruzwa bigaragaza gusa ibisubizo byo kuvumbura imiterere y’uturemangingo twa PEAR1, PTGS1, na GPIIIa ku bantu.