Imiti yumutekano wa Aspirin

Aspirine, nk'umuti mwiza wo kurwanya anti-platelet, ukoreshwa cyane mu gukumira no kuvura indwara z'umutima n'imitsi ndetse n'ubwonko bw'ubwonko.Ubushakashatsi bwerekanye ko abarwayi bamwe basanze badashobora guhagarika neza ibikorwa bya platine nubwo hakoreshwa igihe kirekire cya aspirine, ni ukuvuga kurwanya aspirine (AR). Igipimo kiri hafi 50% -60%, kandi hariho itandukaniro ryamoko. Glycoprotein IIb / IIIa (GPI IIb / IIIa) igira uruhare runini mu kwegeranya platine na trombose ikaze ahantu hakomeretse. Ubushakashatsi bwerekanye ko polymorphism ya gene igira uruhare runini mukurwanya aspirine, cyane cyane yibanda kuri GPIIIa P1A1 / A2, PEAR1 na PTGS1 gene polymorphism. GPIIIa P1A2 ni gene nyamukuru yo kurwanya aspirine. Guhinduka muri iyi gene bihindura imiterere ya reseptor ya GPIIb / IIIa, bikavamo guhuza hagati ya platine no guteranya platine. Ubushakashatsi bwerekanye ko inshuro ya P1A2 alleles ku barwayi barwanya aspirine yari hejuru cyane ugereranije n’abarwayi bumva aspirine, kandi abarwayi bafite ihindagurika ry’abahuje ibitsina P1A2 / A2 bagize ingaruka mbi nyuma yo gufata aspirine. Abarwayi bafite mutant P1A2 alleles barimo gutera stent bafite igipimo cyibintu cya subacute trombotic yikubye inshuro eshanu iy'abarwayi bo mu bwoko bwa P1A1 bahuje igitsina, bisaba dosiye nyinshi ya aspirine kugira ngo bagere ku ngaruka zirwanya anticoagulant. PEAR1 GG allele yitabira neza aspirine, kandi abarwayi bafite genotype ya AA cyangwa AG bafata aspirine (cyangwa ifatanije na clopidogrel) nyuma yo guterwa stent bafite infarction myocardial nimpfu nyinshi. Genotype ya PTGS1 GG ifite ibyago byinshi byo kurwanya aspirine (HR: 10) hamwe n’impanuka nyinshi zifata umutima (HR: 2.55). AG genotype ya AG ifite ibyago bitagereranywa, kandi igomba kwitondera cyane ingaruka zo kuvura aspirine. Ubwoko bwa AA bwumva cyane aspirine, kandi indwara zifata umutima nimiyoboro ni nkeya. Ibisubizo byo gutahura ibicuruzwa byerekana gusa ibisubizo byerekana genes za PEAR1, PTGS1, na GPIIIa.