Guhindura ingingo muri gene ya KRAS bigira uruhare mubibyimba bitandukanye byabantu, aho ihinduka ryimiterere ya 17% - 25% mubwoko bwibibyimba, 15% - 30% muri kanseri yibihaha, na 20% - 50% muri kanseri yibara. Ihinduka ryimiterere itera kuvura no gutera ibibyimba binyuze muburyo bwingenzi: poroteyine ya P21 yashizweho na KRAS ikora epfo na ruguru ya EGFR yerekana inzira. Iyo KRAS imaze guhindurwa, ihora ikora ibimenyetso byerekana epfo na ruguru, igatanga uburyo bwo kuvura EGFR igamije kuvura bidafite ingaruka kandi biganisha ku gukwirakwiza selile mbi. Kubera iyo mpamvu, ihinduka rya KRAS rifitanye isano no kurwanya EGFR tyrosine kinase inhibitor muri kanseri y'ibihaha ndetse no kuvura antibody anti-EGFR muri kanseri yibara.

Mu mwaka wa 2008, Ikigo cy’igihugu gishinzwe kurwanya kanseri (NCCN) cyashyizeho umurongo ngenderwaho w’amavuriro usaba ko KRAS yipimisha ku barwayi bose barwaye kanseri yanduye (mCRC) mbere yo kuvurwa. Amabwiriza agaragaza ko ubwinshi bwimikorere ihindagurika rya KRAS iboneka muri codon ya 12 na 13 za exon 2. Kubwibyo rero, kumenya ihinduka ryihuse kandi ryukuri rya KRAS ni ngombwa mu kuyobora imiti ikwiye.

Impamvu Ikizamini cya KRAS ari ngombwa muriMetastaticColorectalCancer(mCRC)

Kanseri yibara (CRC) ntabwo ari indwara imwe ahubwo ni icyegeranyo cyubwoko butandukanye. Ihinduka rya KRAS-riboneka hafi ya 40-45% by'abarwayi ba CRC-bakora nk'imikorere ihoraho “kuri”, iteza imbere kanseri idashingiye ku bimenyetso byo hanze. Ku barwayi bafite mCRC, imiterere ya KRAS igena imikorere ya antibodiyite zirwanya EGFR nka Cetuximab na Panitumumab:

Ubwoko bw'inyamanswa KRAS:Abarwayi birashoboka ko bazungukirwa no kuvura anti-EGFR.

Mutant KRAS:Abarwayi nta nyungu bahabwa n'aba bakozi, bahura n'ingaruka zitari ngombwa, kongera ibiciro, no gutinda kuvura neza.

Kwipimisha neza kandi byoroshye KRAS rero niyo nkingi ya gahunda yo kuvura yihariye.

Ikibazo cyo Kumenya: Gutandukanya Ikimenyetso cya Mutation

Uburyo gakondo bukunze kubura sensibilité yimiterere ihindagurika ryinshi, cyane cyane mubitegererezo bifite ibibyimba bike cyangwa nyuma ya decalcification. Ingorabahizi iri mu gutandukanya ibimenyetso bya ADN bihindagurika byerekana imiterere yo mu gasozi - nko kubona urushinge muri nyakatsi. Ibisubizo bidahwitse birashobora kuganisha kubuvuzi butari bwo hamwe nibisubizo byangiritse.

Igisubizo cyacu: Igenamigambi-ryakozwe kugirango tumenye ihinduka ryimiterere

KRAS Mutation Detection Kit ihuza tekinoroji igezweho kugirango tuneshe izo mbogamizi, zitanga ubunyangamugayo budasanzwe kandi bwizewe kubuvuzi bwa mCRC.

Uburyo Ikoranabuhanga ryacu ryemeza imikorere isumba iyindi

• Ikoranabuhanga rya ARMS ryongerewe imbaraga (Amplification Refractory Mutation Sisitemu): Yubakiye ku ikoranabuhanga rya ARMS, ririmo tekinoroji yo kuzamura umutungo bwite kugirango yongere umwihariko wo gutahura.
• Enzymatique Enzymatique: Yifashisha kubuza endonuclease kugirango igogore igice kinini cyimiterere yimiterere yimiterere yimiterere yimiterere yimiterere yabantu, ikarinda ubwoko bwa mutant, bityo ikongerera imbaraga zo gutahura no kugabanya amplificatif idasanzwe bitewe na genomique yo hejuru.
• Guhagarika ubushyuhe: Itangiza intambwe yihariye yubushyuhe mubikorwa bya PCR, bigatera kudahuza hagati ya mutant primers nubwoko bwinyamanswa, bityo bikagabanya imiterere yubwoko kandi bikanoza gukemura.
• Ibyiyumvo Byinshi: Kumenya neza nka ADN ya mutant 1%.
• Ubwiza buhebuje: Koresha ibipimo byimbere hamwe na enzyme ya UNG kugirango wirinde ibisubizo byiza nibibi.
• Byoroshye kandi Byihuse: Kurangiza ikizamini muminota igera kuri 120, ukoresheje tebes ebyiri zifata kugirango byorohereze kumenya ihinduka ryimiterere umunani itandukanye, bitanga ibisubizo bifatika kandi byizewe.
• Guhuza ibikoresho: Bihuza nibikoresho bitandukanye bya PCR.

Ubuvuzi bwuzuye muri kanseri yibara butangirana no gusuzuma neza molekile. Mugukoresha KRAS Mutation Detection Kit, laboratoire yawe irashobora gutanga ibisubizo byuzuye, bifatika byerekana inzira yo kuvura umurwayi.

Ongera laboratoire yawe hamwe na tekinoroji yizewe, kandi igushoboze kwita kubantu kugiti cyabo.

Twandikire: kwamamaza @ mmtest.Com

Wige byinshi bijyanye no kwinjiza iki gisubizo cyiterambere mubikorwa byawe byo gusuzuma.

#Amabara

Gufungura Ubuvuzi Bwuzuye muri Kanseri yibara

https://www.linkedin.com/post//cro