Uburyo bwo kuvura bwa Open Precision kuri NSCLC hakoreshejwe uburyo bwo gusuzuma impinduka za EGFR mutation bugezweho

Kanseri y'ibihaha iracyari ikibazo cy'ubuzima ku isi, ikaba ari yo kanseri ya kabiri ikunze kugaragara cyane. Mu 2020 gusa, hagaragaye abantu bashya barenga miliyoni 2.2 ku isi. Kanseri y'ibihaha itari iy'uturemangingo duto (NSCLC) ihagarariye abarenga 80% by'indwara zose za kanseri y'ibihaha, bigaragaza ko hakenewe ingamba zo kuvura zigamije kandi zinoze.

Impinduka za EGFR zagaragaye nk'inkingi ikomeye mu kuvura NSCLC ku giti cyazo. Inzobere za EGFR tyrosine kinase inhibitors (TKIs) zitanga uburyo bushya bwo kugabanya ibimenyetso bitera kanseri, zikabuza gukura kwa kanseri, kandi zigatuma uturemangingo twa kanseri dupfa—byose mu gihe bigabanya kwangirika kw'uturemangingo tuzima.

Amabwiriza y’ubuvuzi akomeye, harimo na NCCN, ubu ategeka ko hakorwa isuzuma rya EGFR mutation mbere yo gutangira ubuvuzi bwa TKI, kugira ngo abarwayi bakwiye babone imiti ikwiye kuva mu ntangiriro.

Impinduka za EGFR zagaragaye nk'inkingi ikomeye mu kuvura NSCLC ku giti cyazo. Inzobere za EGFR tyrosine kinase inhibitors (TKIs) zitanga uburyo bushya bwo kugabanya ibimenyetso bitera kanseri, zikabuza gukura kwa kanseri, kandi zigatuma uturemangingo twa kanseri dupfa—byose mu gihe bigabanya kwangirika kw'uturemangingo tuzima.

Amabwiriza y’ubuvuzi akomeye, harimo na NCCN, ubu ategeka ko hakorwa isuzuma rya EGFR mutation mbere yo gutangira ubuvuzi bwa TKI, kugira ngo abarwayi bakwiye babone imiti ikwiye kuva mu ntangiriro.

Tubagezaho uburyo bwo gupima imiterere y’ibinyabuzima mu buryo bwa EGFR Gene 29 (Fluorescence PCR)
Gusuzuma neza uburyo bwo gufata ibyemezo bihamye byo kuvura

Akamashini ko gusuzuma EGFR ka Macro & Micro-Test gatuma umuntu amenya byihuse kandi neza impinduka 29 z'ingenzi kuri exons 18-21 haba mu biopsies by'inyama n'ibikomoka ku mazi - gaha imbaraga abaganga guhindura uburyo bwo kuvura bafite icyizere.

Impamvu yo GuhitamoIsuzuma rya Macro na Micro'sAgakoresho ko gupima EGFR?

Iyi kit isuzuma impinduka 29 zisanzwe za EGFR muri exons 18-21 ziturutse ku ngirabuzima fatizo cyangwa amaraso y'abarwayi ba NSCLC, ikaba ikubiyemo ahantu hashobora kwanduzwa imiti n'aho imiti idashobora kuyirwanya kugira ngo iyobore ikoreshwa ry'imiti yibasiwe nka gefitinib na osimertinib.

1. 1. Ikoranabuhanga rya ARMS Rinoze: ARMS Yongerewemo imashini yongerera ubushobozi ifite patenti kugira ngo irusheho kuba nziza;
2. 2. Kunoza imikorere y’uturemangingo: Bigabanya imiterere y’uturemangingo tw’umwimerere binyuze mu gusya imiterere y’uturemangingo, kunoza uburyo bwo kubitahura no kugabanya kwiyongera kudasanzwe bitewe n’imiterere y’uturemangingo twinshi;
3. 3. Guhagarika ubushyuhe: Byongera ibyiciro byihariye by'ubushyuhe mu buryo bwa PCR, bigabanya ukutumvikana no kongera uburyo bwo kubitahura neza;
4. 4. Ubushobozi bwo kwiyumvamo ibintu byinshi: Imenya impinduka ziri hasi cyane nka 1% by'impinduka;
5. 5. Ubuziranenge Buhebuje: Igenzura ry'imbere na enzyme ya UNG kugira ngo bigabanye ibisubizo bitari byo;
6. 6. Ingufu: Ibisubizo by'intego mu minota 120
7. 7. Inkunga y'icyitegererezo cy'ibice bibiri - Yagenewe ingero z'imitsi n'amaraso, itanga ubushobozi bwo koroshya ibikorwa byo kwa muganga
8. 8. Guhuza neza: Bijyanye cyane n'ibikoresho bya PCR bizwi ku isoko;
9. 9. Igihe cyo kumara: amezi 12.

Gutanga Ubuvuzi bw'Inyigisho n'Icyizere
Iyi kit ifasha mu kongera umusaruro w’ubuvuzi no kuguma imbere y’ubudahangarwa hamwe n’uburyo bwo kumva no guhindagurika kw’ubudahangarwa.

Kwagura porogaramu yawe ya Precision Oncology
Suzuma uburyo bwose bwo gusuzuma impinduka mu miterere y'umubiri kuri KRAS, BRAF, ROS1, ALK, BCR-ABL, TEL-AML1, n'ibindi—byose bigamije gushyigikira ubuvuzi busesuye bushingiye ku bipimo ngenderwaho.

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