Guhindura C. diff Gusuzuma: Kugera ku bushakashatsi bwikora, bwerekana uburyo bwo gusuzuma molekile mu buryo bwikora

Ni iki gitera kwandura C. Diff?

1. Ubwandu bwa Diff buterwa na bagiteri izwi nka Clostridioides difficile (C. difficile), ikunze kuba mu mara nta kibazo. Ariko, iyo bagiteri zigenda zihungabana mu mara, akenshi hakoreshwa imiti yica udukoko twinshi,C. bigoyeishobora gukura cyane ikabyara uburozi, bigatera kwandura.

Iyi bagiteri iba mu buryo bwa toxigenic n'ubutari toxigenic, ariko ubwoko bwa toxigenic (uburozi A na B) ni bwo butera indwara gusa. Butera ububyimbirwe bubangamira uturemangingo tw’amara. Toxice A ni uburozi bw’inkeri bwangiza ururenda rw’amara, bukongera ubushobozi bwo kwinjira mu mara, kandi bugakurura uturemangingo tw’ubudahangarwa busohora utunyangingo tw’ububyimbirwe. Toxice B, uburozi bukomeye cyane, bwibasira urugingo rwa actin rw’uturemangingo, biganisha ku kuzunguruka kw’uturemangingo, gutandukana kw’uturemangingo, ndetse amaherezo n’urupfu rw’uturemangingo. Ubwo burozi butera kwangirika kw’uturemangingo no gukora neza k’ubudahangarwa bw’umubiri, bigaragarira mu ndwara ya colitis, impiswi, kandi mu bihe bikomeye, indwara ya pseudomembranous colitis—ububyimbirwe bukomeye bw’amara.

C. Diff ikwirakwira ite?

1. Ikwirakwira byoroshye cyane. Iboneka mu bitaro, ikunze kuboneka mu byumba bitanga ubutabazi bw’ibanze, ku maboko y’abakozi b’ibitaro, hasi no ku byuma bifasha mu kuvura indwara, kuri termometero z’ikoranabuhanga, n’ibindi bikoresho by’ubuvuzi…

Ibintu bishobora gutera indwara ya C. Diff

• Kujyanwa mu bitaro igihe kirekire;
• Uburyo bwo kuvura mikorobe;
• Imiti ivura indwara za chimiotherapie;
• Kubagwa vuba aha (amaboko yo mu nda,inzira yo kunyuramo igifu, kubagwa amara menshi);
• Indyo yo mu nda no mu gifu;
• Ubwandu bwa C. diff mbere;

Ibimenyetso bya C. Diffuse yanduriye

Kwandura C. diff bishobora kubabaza cyane. Abantu benshi bahorana impiswi n'ububabare mu nda. Ibimenyetso bikunze kugaragara ni:impiswi, kubabara mu gifu, isesemi, kubura ubushake bwo kurya, umuriro.

Uko ubwandu bwa C. diff burushaho gukomera, hazabaho ubwoko bugoye bwa C. diff buzwi nkaindwara ya colitis, pseudomembranous enteritis ndetse n'urupfu.

Gusuzuma indwara ya C. Diff

Umuco wa bagiteri: Ifite ubushishozi arikobitwara igihe (iminsi 2-5), ntashobora gutandukanyaubwoko bw'ibiyobyabwenge bitera uburozi n'ibitari byo;

Umuco w'uburozi:igaragaza ubwoko bw'uburozi butera indwara ariko bifata igihe kinini (iminsi 3-5) kandi budakunze kugaragara;

Gupima GDH:yihuta (amasaha 1-2) kandi ihendutse, irakomeye cyane ariko ntishobora gutandukanya ubwoko bw'ibihumanya n'ibitari ibihumanya;

Isuzuma rya Cytotoxicity Neutralization Assay (CCNA):isuzuma uburozi A na B ifite ubushobozi bwo kuvura indwara ariko itwara igihe kinini (iminsi 2-3), kandi ikenera ibikoresho byihariye n'abakozi babihuguriwe;

Uburozi A/B ELISA: Ikizamini cyoroshye kandi cyihuse (amasaha 1-2) gifite ubushobozi buke bwo kumva no kugaragaza ibimenyetso bitari byo;

Ibipimo byo kongera aside ya nucleike (NAATs): Yihuta (amasaha 1-3) kandi ifite ubushishozi bwinshi kandi yihariye, ikamenya uturemangingo dutuma habaho uburozi;

Byongeye kandi, ibizamini byo gusuzuma amara, nkogupima CT (CT scan)naImirasire ya X, ishobora kandi gukoreshwa mu gufasha mu gusuzuma C. diff n'ingorane za C. diff, nka colitis.

Uburyo bwo kuvura indwara ya C. Diff

Hari uburyo bwinshi bwo kuvura indwara ya C. diff. Dore uburyo bwiza bwo kuvura:

• Antibiyotike zinyobwa nka vancomycin, metronidazole cyangwa fidaxomicin zikunze gukoreshwa kuko umuti ushobora kunyura mu mfuruka ukagera mu mara aho bagiteri ya C. diff iba.
• Metronidazole yo mu mitsi ishobora gukoreshwa mu kuvura iyo ubwandu bwa C. diff bukabije.
• Gutera microbiota mu mwanda byagaragaje ko bigira akamaro mu kuvura indwara za C. diff zikunze kugaragara ndetse n'indwara zikomeye za C. diff zidakira imiti yica udukoko.
• Kubagwa bishobora kuba ngombwa ku ndwara zikomeye.

Udushya twa digisubizo cy'isuzuma gitangwa na MMT

Mu rwego rwo gukemura ikibazo cyo gupima C. difficile byihuse kandi neza, twashyizeho uburyo bushya bwo gupima aside nucleic acid kuri gene A/B y’uburozi bwa Clostridium difficile, duha imbaraga abaganga mu gusuzuma hakiri kare kandi neza no gushyigikira kurwanya indwara zandurira mu bitaro.

• Ubushobozi bwo kugaragaza ibyiyumvo bikabije: Ibona ko hari hasi cyane nka200 CFU/mL,;
• Intego ikwiye: Igaragaza neza neza C. bigoyegene y'uburozi A/B, kugabanya ibyavuye mu bushakashatsi bitari byo;
• Gusuzuma indwara mu buryo butaziguye: Ikoresha isuzuma rya aside nucleique kugira ngo imenye neza gene z'uburozi, ishyiraho igipimo ngenderwaho cy'ubuziranenge mu gusuzuma.
• Irahuye neza naIbikoresho bya PCR bikoreshwa mu bushakashatsi bwinshi;

Igisubizo cy'icyitegererezo cyo gusubiza kiri kuriIsuzuma rya Macro na Micro'sAIO800Laboratwari ya PCR igendanwa

Uburyo bwo gukora ikizamini cyo gusubiza – Shyira imiyoboro y’icyitegererezo y’umwimerere (1.5–12 mL) mu buryo butaziguye, bikuraho imiyoboro ikoreshwa n’intoki. Gukuramo, kongera ubushobozi bwo gukora ikizamini no kugitahura bikorwa mu buryo bwikora, bigabanya igihe cyo gukorana n’abantu n’amakosa.

• Uburinzi bw'Ibyanduzwa mu byiciro 11 - Inzira y'umwuka inyura mu cyerekezo, umuvuduko mubi, kuyungurura HEPA, gusukura UV, gukora ibikorwa bifunze, n'ubundi buryo bwo kurinda abakozi kandi butanga ibisubizo byizewe mu gihe cyo gupima umusaruro mwinshi.

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