Kanseri y'ibihaha ikomeje kuba imwe mu mpamvu zikomeye zitera impfu ziterwa na kanseri ku isi, ahoKanseri y'ibihaha itari nto (NSCLC) ifata hafi 85% by'abarwayi bose.Mu myaka ibarirwa muri za mirongo, ubuvuzi bwa NSCLC buteye imbere bwashingiye ahanini ku miti ya chimiotherapie, igikoresho kidakora neza kitagiraga ingaruka nziza kandi gifite uburozi bukabije.
Impinduka mu kuvura zatangiye ubwo havumburwaga "impinduka mu mikorere y'ibinyabiziga" - impinduka zihariye mu mikorere y'uturemangingo zitera kwiyongera kwa kanseri. Ibi byatumye habaho uburyo bwo kuvura bwibasiwe, bukora nk'ibisasu biyobowe neza, bigasenya uturemangingo twa kanseri mu buryo bwihariye ariko bikarinda utuzima. Ariko, kugira ngo ubwo buryo buvuguruye bugere ku ntsinzi y'ubu buryo bwo kuvura bushingiye ku gupima neza no kwizerwa kugira ngo hamenyekane umurwayi ukwiye.
Ibimenyetso by'ingenzi by'ibinyabuzima: EGFR, ALK, ROS1, na KRAS
Ibipimo bine by'ubuzima ni inkingi zikomeye mu gusuzuma NSCLC, biyobora ibyemezo by'ubuvuzi bw'umurongo wa mbere:
-EGFR:Impinduka zikunze kugaragara cyane, cyane cyane mu baturage bo muri Aziya, abagore, n'abatanywa itabi. Indwara zo mu bwoko bwa EGFR tyrosine kinase inhibitors (TKIs) nka Osimertinib zazamuye cyane ingaruka ku barwayi.
-ALK:"Impinduka mu mikorere ya diyama," igaragara muri 5-8% by'abarwayi ba NSCLC. Abarwayi bafite ALK fusion bakunze kwita cyane ku miti igabanya ALK, bigatuma bakomeza kubaho igihe kirekire.
-ROS1:Iyi "gaciro gake" iboneka ku barwayi ba NSCLC bari hagati ya 1-2%, bityo kuyipima ni ingenzi cyane.
-KRAS:Mu mateka, impinduka za KRAS zafatwaga nk' "zidakoreshwa mu miti," zirakunze kugaragara. Kwemerwa vuba aha kwa KRAS G12C inhibitors byahinduye iyi biomarker kuva ku kimenyetso cy'ibizamini bihinduka intego ishobora gukorwa, bihindura uburyo bwo kwita ku barwayi.
Porogaramu ya MMT: Yakozwe mu rwego rwo kugira icyizere cyo gusuzuma indwara
Kugira ngo habeho ibyifuzo byihutirwa byo kumenya neza ibimenyetso by’ibipimo by’ubuzima, MMT itanga ibikoresho byo gupima PCR byanditseho CE-IVD mu gihe nyacyo, buri kimwe cyakozwe mu ikoranabuhanga rigezweho kugira ngo gikomeze kwizezwa n’isuzuma ry’indwara.
1. Agakoresho ko Gusuzuma Impinduka za EGFR
-Ikoranabuhanga rya ARMS Rinoze:Inyongeramusaruro z’umutungo wo mu nzu zongerera ubushobozi bwo kongera ubwiyongere bw’impinduka mu mubiri.
-Kunoza enzyme:Ingufu za restriction endonucleases zigabura inyuma ya genome yo mu bwoko bwa wild-type, zikongera imiterere ya mutant kandi zikongera ubushobozi bwo gusubiza ibintu mu buryo.
-Kubuza ubushyuhe:Intambwe yihariye y'ubushyuhe igabanya priming idasobanutse, birushaho kugabanya inyuma y'ubwoko bw'ishyamba.
-Ibyiza by'ingenzi:Uburyo bwo kumva ibintu butagereranywa kugeza kuri1%inshuro za allele zitarahinduka, ubuhanga buhanitse hamwe n'igenzura ry'imbere na enzyme ya UNG, hamwe n'igihe cyihuse cyo guhindura ibintu hafi yaIminota 120.
- Ijyanye naingero za biopsy z'inyama n'iz'amazi.
2.Kit yo Gutahura Fusion ya MMT EML4-ALK
- Ubushobozi bwo kugaragaza ibyiyumvo (sensitivity) buri hejuru:Imenya neza impinduka za fusion hamwe n'aho ntarengwa yo kubimenya inshuro 20 ku busabe.
-Ubuziranenge Bwiza:Ishyiramo amahame y’imbere mu kugenzura ibikorwa n’imisemburo ya UNG kugira ngo hirindwe kwanduzwa n’ibintu bihumanya ikirere, hirindwa ingaruka mbi n’ibitari byo.
-Byoroshye kandi byihuse:Ifite igikorwa cyoroshye kandi gifunze cyakozwe mu minota 120.
-Guhuza Ibikoresho:Ishobora gukoreshwa n'ibikoresho bitandukanye bisanzwe bya PCR mu gihe nyacyo, itanga ubushobozi bwo gukora muri laboratwari iyo ari yo yose.
3.Kit yo Gutahura Fusion ya MMT ROS1
Ubushobozi bwo kugaragaza ibyiyumvo (sensitivity) buri hejuru:Igaragaza imikorere idasanzwe mu kubona neza ko hari kopi nkeya za 20/uburyo intego za fusion zakozwe.
Ubuziranenge Bwiza:Gukoresha uburyo bwo kugenzura ubuziranenge bw'imbere n'imisemburo ya UNG bitanga icyizere cy'uko buri gisubizo cyose cyaba cyizewe, bigabanya ibyago byo gutangaza amakosa.
Byoroshye kandi byihuse:Nk'uburyo bwo gufunga imiyoboro, nta ntambwe zigoye zisaba nyuma yo kongera ingufu. Ibisubizo by'ingenzi kandi byizewe biboneka mu minota 120.
Guhuza Ibikoresho:Yagenewe guhuza neza n'imashini zitandukanye za PCR, byoroshya uburyo bworoshye bwo guhuza n'imikorere ya laboratwari isanzweho.
4. Kit yo Gusuzuma Impinduka za MMT KRAS
- Ikoranabuhanga rya ARMS ryongerewe imbaraga, rikomezwa na Enzymatic Enrichment na Terimitation.
- Kunoza enzyme:Ikoresha restriction endonucleases kugira ngo ihinge neza inyuma ya genome yo mu bwoko bwa wild-type, bityo ikongerera ubwinshi bw'amahinduka kandi ikongera cyane ubushobozi bwo kumenya.
-Kubuza ubushyuhe:Itanga intambwe yihariye y'ubushyuhe kugira ngo itere itandukaniro hagati ya primers zihariye za mutant na templates zo mu bwoko bwa wild-type, igabanya inyuma kandi inoza umwihariko.
- Ubushobozi bwo kugaragaza ibyiyumvo (sensitivity) buri hejuru:Igera ku kigero cya 1% cy’ubushobozi bwo kumenya alleles zahinduwe, ikemeza ko hamenyekana impinduka nkeya.
-Ubuziranenge Bwiza:Amahame y’imbere ahujwe hamwe na enzyme ya UNG birinda ibisubizo bitari byo byiza n’ibibi.
-Itsinda ry'Abakozi Rirambuye:Yakozwe neza kugira ngo yorohereze kubona impinduka umunani zitandukanye za KRAS mu miyoboro ibiri gusa y'impinduka.
- Byoroshye kandi byihuse:Itanga umusaruro ufatika kandi wizewe mu minota 120.
- Guhuza Ibikoresho:Ihuza neza n'ibikoresho bitandukanye bya PCR, itanga uburyo butandukanye bwo gukoresha muri laboratwari z'ubuvuzi.
Kuki wahitamo igisubizo cya MMT NSCLC?
Byuzuye: Urutonde rwuzuye rw'ibipimo bine by'ingenzi cyane bya NSCLC.
Ikoranabuhanga Rihambaye: Kongera imiterere y'umutungo (Guteza imbere Enzymatic, Gufunga ubushyuhe) bitanga ubushobozi bwo kugaragaza imiterere n'ubushobozi bw'umuntu aho bikenewe cyane.
Byihuse kandi Binoze: Porogaramu imwe y'iminota 120 muri porogaramu yihutisha igihe cyo kuvurwa.
Yoroshye kandi yoroshye kubona: Ihuye n'ubwoko bwinshi bw'ibipimo n'ibikoresho bya PCR bisanzwe, bigabanya inzitizi zo kuyishyira mu bikorwa.
Umwanzuro
Muri iki gihe cy’ubuvuzi bwa kanseri bugezweho, gusuzuma indwara za molekile ni byo biyobora inzira zo kuvura. Ibikoresho bigezweho bya MMT bifasha abaganga gupima neza imiterere y’uturemangingo tw’umurwayi, bigatuma bashobora kurokora ubuzima bw’umurwayi.
Contact to learn more: marketing@mmtest.com
Igihe cyo kohereza: Ukwakira 14-2025