Icyitegererezo cyuzuye cyo gusubiza C. Gupima itandukaniro ry'ubwandu

Ni iki gitera kwandura C. Diff?

Ubwandu bwa C.Diff buterwa na bagiteri izwi nkaClostridioides difficile (C. difficile), akenshi iba mu mara nta kibazo. Ariko, iyo bagiteri zihungabanye mu mara, akenshi ikoreshwa rya antibiyotike nyinshi, C. difficile ishobora gukura cyane ikabyara uburozi, bigatera kwandura.

Iyi bagiteri iba muri zombiitera uburozin'imiterere idakomoka ku burozi, ariko ubwoko bwa toxigen (uburozi A na B) ni bwo butera indwara. Butera ubushyuhe bubangamira uturemangingo tw'amara. Toxicity A ni uburozi bw'inkentone bwangiza ururenda rw'amara, bukongera ubushobozi bwo kwinjira mu mara, kandi bugakurura uturemangingo tw'ubudahangarwa busohora uburozi bw'inka. Toxicity B, uburozi bw'inka bukomeye cyane, bwibasira urugingo rwa actin cytoskeleton rw'uturemangingo, bigatera urugingo kwizunguruka, kwitandukanya, ndetse amaherezo n'urupfu rw'uturemangingo. Ubwo burozi butera kwangirika kw'ingingo n'uburyo ubudahangarwa bw'umubiri bukora neza, bigaragarira mu ndwara ya colitis, impiswi, kandi mu bihe bikomeye, indwara ya pseudomembranous colitis—ubushyuhe bukomeye bw'amara.

Bigenda biteC. Itandukanirogukwirakwira?

C.Diff ikwirakwira byoroshye cyane. Iboneka mu bitaro, ikunze kuboneka mu byumba bitanga impagarara nini, ku maboko y'abakozi b'ibitaro, hasi no ku byuma bifasha mu kuvura indwara, kuri termometero z'ikoranabuhanga, n'ibindi bikoresho by'ubuvuzi...

Ibintu bishobora gutera indwara ya C. Diff

• ●Kujyanwa mu bitaro igihe kirekire;

• ●Uburyo bwo kuvura mikorobe;

• ●Imiti ivura indwara za chimiotherapie;

• ●Kubagwa vuba aha (gukoresha amaboko yo mu gifu, gusimbuka igifu, kubagwa umara muke);

• ●Indyo yo mu nda no mu gifu;

• ●Ubwandu bwa C. diff mbere;

Ibimenyetso bya C. Diffuse yanduriye

Kwandura C. diff bishobora kubabaza cyane. Abantu benshi bahorana impiswi n'ububabare mu nda. Ibimenyetso bikunze kugaragara ni: impiswi, kubabara mu gifu, isesemi, kubura ubushake bwo kurya, umuriro.

Uko ubwandu bwa C. diff burushaho gukomera, hazabaho ubwoko bugoye bwa C. diff buzwi nka colitis, pseudomembranous enteritis ndetse n'urupfu.

Isuzumaindwara ya C. Diff

Umuco wa bagiteri:Ifite ubukana ariko itwara igihe (iminsi 2-5), ntishobora gutandukanya ubwoko bw'uburozi n'ubutari uburozi;

Umuco w'uburozi:igaragaza ubwoko bw'uburozi butera indwara ariko bifata igihe kinini (iminsi 3-5) kandi budakunze kugaragara;

Gupima GDH:yihuta (amasaha 1-2) kandi ihendutse, irakomeye cyane ariko ntishobora gutandukanya ubwoko bw'ibihumanya n'ibitari ibihumanya;

Isuzuma rya Cytotoxicity Neutralization Assay (CCNA):isuzuma uburozi A na B ifite ubushobozi bwo kuvura indwara ariko itwara igihe kinini (iminsi 2-3), kandi ikenera ibikoresho byihariye n'abakozi babihuguriwe;

Uburozi A/B ELISA: Ikizamini cyoroshye kandi cyihuse (amasaha 1-2) gifite ubushobozi buke bwo kumva no kugaragaza ibimenyetso bitari byo;

Ibipimo byo kongera aside ya nucleike (NAATs): Yihuta (amasaha 1-3) kandi ifite ubushishozi bwinshi kandi yihariye, ikamenya uturemangingo dutuma habaho uburozi;

Byongeye kandi, ibizamini byo gusuzuma amara, nka CT scan na X-ray, bishobora no gukoreshwa mu gufasha mu gusuzuma C. diff n'ingorane za C. diff, nka colitis.

Uburyo bwo kuvura indwara ya C. Diff

Hari uburyo bwinshi bwo kuvuraC. kwandura indwara zitandukanyeDore amahitamo meza:

• ●Antibiyotike zinyobwa nka vancomycin, metronidazole cyangwa fidaxomicin zikunze gukoreshwa kuko umuti ushobora kunyura mu mfuruka ukagera mu mara aho bagiteri ya C. diff iba.

• ●Metronidazole yo mu mitsi ishobora gukoreshwa mu kuvura iyo ubwandu bwa C. diff bukabije.

• ●Gutera microbiota mu mwanda byagaragaje ko bigira akamaro mu kuvura indwara za C. diff zikunze kugaragara ndetse n'indwara zikomeye za C. diff zidakira imiti yica udukoko.

• ●Kubagwa bishobora kuba ngombwa ku ndwara zikomeye.

Igisubizo cyo gusuzuma indwara gitangwa na MMT

Mu rwego rwo gukemura ikibazo cyo gupima C. difficile byihuse kandi neza, twashyizeho uburyo bushya bwo gupima aside nucleic acid kuri gene A/B y’uburozi bwa Clostridium difficile, duha imbaraga abaganga mu gusuzuma hakiri kare kandi neza no gushyigikira kurwanya indwara zandurira mu bitaro.

图片链接：

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  ●Ubushobozi bwo kugaragaza ibyiyumvo bikabije: Ibona ko hari hasi cyane nka200 CFU/mL,;

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  ●Intego ikwiye: Igaragaza neza gene ya A/B y’uburozi bwa C. difficile, igagabanya ibimenyetso bitari byo;

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  ●Gusuzuma indwara mu buryo butaziguye: Ikoresha isuzuma rya aside nucleique kugira ngo imenye neza gene z'uburozi, ishyiraho igipimo ngenderwaho cy'ubuziranenge mu gusuzuma.

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  ●Irahuye neza naIbikoresho bya PCR bikoreshwa mu bushakashatsi bwinshi;

Urugero rw'igisubizoIgisubizo kuri Lab ya Macro & Micro-Test ya AIO800 Mobile PCR

 

• ●Uburyo bwo gukora ikizamini cyo gusubiza – Shyira imiyoboro y’icyitegererezo y’umwimerere (1.5–12 mL) mu buryo butaziguye, bikuraho imiyoboro ikoreshwa n’intoki. Gukuramo, kongera ubushobozi bwo gukora ikizamini no kugitahura bikorwa mu buryo bwikora, bigabanya igihe cyo gukorana n’abantu n’amakosa.

• ●Uburinzi bw'Indangagaciro mu byiciro umunani - Inzira y'umwuka inyura mu cyerekezo, umuvuduko mubi, kuyungurura HEPA, gusukura UV, gukora ibikorwa bifunze, n'ubundi buryo bwo kurinda abakozi kandi butanga ibisubizo byizewe mu gihe cyo gupima umusaruro mwinshi.

Ku bindi bisobanuro:

https://www.mmtest.com/nucleic-acid-detection-kit-for-clostridium-difficile-toxin-ab-gene-fluorescence-pcr-product/

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