Gupima mRNA ya HR-HPV yo mu bwoko bwa 15-Type – Bigaragaza ko HR-HPV ihari n'uko ikora

Kanseri y'inkondo y'umura, intandaro ikomeye y'impfu mu bagore ku isi, iterwa ahanini n'ubwandu bwa HPV. Ubushobozi bwa HR-HPV bwo kwandura kanseri bushingiye ku kwiyongera kw'uturemangingo twa E6 na E7. Poroteyine za E6 na E7 zigira uruhare mu gufatana na poroteyine zigabanya ikibyimba p53 na pRb, kandi zigatuma uturemangingo tw'inkondo y'umura twiyongera kandi tugahinduka.

Ariko, isuzuma rya ADN rya HPV ryemeza ko virusi ihari, ntiritandukanya ubwandu bwihishe n’ubwandu bwinjira mu buryo bufatika. Mu buryo bunyuranye, kumenya inyandiko za mRNA za HPV E6/E7 bitanga ishusho yihariye y’igaragara rya oncogene ya virusi, bityo, bikaba ari ikimenyetso cy’ukuri cy’indwara yo mu mura w’inkondo y’umura (CIN) cyangwa kanseri y’inkondo y’umura.

HPV E6/E7 mRNAgupima bitanga inyungu zikomeye mu kwirinda kanseri y'inkondo y'umura:

• Isuzuma ry’Ingaruka Nyayo: Rigaragaza ubwandu bwa HPV burimo ibyago byinshi, ritanga isuzuma ry’ingaruka nyazo kurusha isuzuma rya ADN rya HPV.
• Isuzuma rikora neza: Rifasha abaganga kumenya abarwayi bakeneye iperereza ryinshi, rigabanya uburyo bwo kuvura butari ngombwa.
• Igikoresho cyo gusuzuma gishobora gukoreshwa: Kishobora gukoreshwa nk'igikoresho cyo gusuzuma cyihariye mu gihe kizaza, cyane cyane ku bantu bafite ibyago byinshi byo kwandura.
• Ubwoko 15 bwa Papillomavirusi y’abantu ifite ibyago byinshi byo kwandura Gene mRNA E6/E7 (Fluorescence PCR) ituruka kuri #MMT, igaragaza neza ikimenyetso cy’ubwandu bushobora gutera imbere bwa HR-HPV, ni igikoresho cy’ingirakamaro cyo gusuzuma HPV no/cyangwa kwita ku barwayi.

Ibiranga ibicuruzwa:

• Ubuvuzi bwuzuye: Ubwoko 15 bwa HR-HPV bufitanye isano na kanseri y'inkondo y'umura burimo;
• Uburyo bworoshye bwo gupima: kopi 500/mL;
• Ubwihariye bwo hejuru: Nta gikorwa kijyanye na cytomegalovirus, HSV II na ADN y'uturemangingo tw'umubiri w'umuntu;
• Kugabanya ikiguzi: Intego zo gupima zifitanye isano rya hafi n'indwara ishobora kubaho, kugira ngo bigabanye ibizamini bitari ngombwa hamwe n'amafaranga y'inyongera;
• Uburinganire bwiza cyane: IC kuri gahunda yose;
• Guhuza neza: Hamwe na sisitemu za PCR zisanzwe;