Clostridium Difficile Glutamate Dehydrogenase (GDH) na Toxin A/B

Clostridium difficile (CD) ni bacillus idafite gram-positive, ikaba ari imboga zisanzwe mu mubiri w'umuntu. Izindi mboga zizabuzwa kugwira bitewe n'imiti ikoreshwa mu bipimo byinshi, kandi CD ikororoka mu mubiri w'umuntu ku bwinshi. CD igabanyijemo ubwoko butanga uburozi n'ubudatanga uburozi. Ubwoko bwose bwa CD bukora glutamate dehydrogenase (GDH) iyo bwororoka, kandi ubwoko bwa toxigenic ni bwo bwonyine butera indwara. Ubwoko butanga uburozi bushobora gukora uburozi bubiri, A na B. Toxicity A ni enterotoxin, ishobora gutera kubyimba urukuta rw'amara, kwinjira mu turemangingo, kwiyongera k'urukuta rw'amara, kuva amaraso no kwangirika. Toxicity B ni cytotoxin, yangiza cytoskeleton, igatera pyknosis na necrosis y'uturemangingo, kandi ikangiza uturemangingo tw'amara mu buryo butaziguye, bigatera impiswi na pseudomembranous colitis.