Clostridium Difficile Glutamate Dehydrogenase (GDH) na Toxin A / B.

Clostridium difficile (CD) ni anaerobic gram-positif ya bacillus, ni flora isanzwe mumubiri wumuntu.Ibindi bimera bizabuzwa kugwira bitewe na antibiyotike zikoreshwa muri dosiye nini, kandi CD yororoka mumubiri wabantu ku bwinshi.CD igabanyijemo amoko atanga uburozi kandi adatanga uburozi.Ubwoko bwose bwa CD butanga glutamate dehydrogenase (GDH) iyo yororoka, kandi ubwoko bwa toxigenic bwonyine butera indwara.Ubwoko butanga uburozi bushobora kubyara uburozi bubiri, A na B. Toxin A ni enterotoxine, ishobora gutera uburibwe bwurukuta rw amara, kwinjira mu ngirabuzimafatizo, kwiyongera kwurukuta rw amara, kuva amaraso hamwe na nérosose.Uburozi B ni cytotoxine, yangiza cytoskeleton, itera pyknose selile na necrosis, kandi yangiza mu buryo butaziguye ingirabuzimafatizo zo mu nda, bikaviramo impiswi na kolite pseudomembranous.