ALDH Imiterere ya Polymorphism

ALDH2 gene (acetaldehyde dehydrogenase 2), iherereye kuri chromosome yabantu 12. ALDH2 ifite esterase, dehydrogenase hamwe na reductase icyarimwe. Ubushakashatsi bwerekanye ko ALDH2 ari enzyme ya metabolike ya nitroglycerine, ihindura nitrogliserine muri okiside ya nitric, bityo ikorohereza imiyoboro y'amaraso no kunoza imivu y'amaraso. Ariko, hariho polymorphism muri gen ALDH2, yibanda cyane muri Aziya y'Uburasirazuba. Ubwoko bwa gasozi ALDH2 * 1 / * 1 GG ifite ubushobozi bukomeye bwo guhinduranya, mugihe ubwoko bwa heterozygous bufite 6% gusa yibikorwa byo mu bwoko bwa enzyme yo mu gasozi, kandi ubwoko bwa mutant bahuje ibitsina bufite ibikorwa bya enzyme hafi ya zeru, hamwe na metabolism ifite intege nke cyane kandi ntibishobora kugera ku ngaruka zifuzwa ku mubiri w'umuntu.